The antiinflammatory activity of IgG: the intravenous IgG paradox
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چکیده
منابع مشابه
The antiinflammatory activity of IgG: the intravenous IgG paradox
How high doses of intravenous IgG (IVIG) suppress autoimmune diseases remains unresolved. We have recently shown that the antiinflammatory activity of IVIG can be attributed to a minor species of IgGs that is modified with terminal sialic acids on their Fc-linked glycans. Here we propose that these Fc-sialylated IgGs engage a unique receptor on macrophages that, in turn, leads to the upregulati...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2007
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20061788